Book through our site
—up to 10% cheaper
than Booking.com
Check rooms and rates
From148US$ /night
Check-in
27Jan2026Select date
Check-out
28Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

601 Main Street, Buffalo, New York, United States, 14203
-
Close to Fountain Plaza
Very good
7.8
8.4
/10
4.3
3.9
/5

Location

Located within Buffalo's Theatre District, Holiday Inn Express & Suites Buffalo Downtown is just a block away from the Buffalo Passport Agency and only minutes from Canalside. The hotel is also close to notable venues such as Shea's Performing Arts Center and Key Bank Center, both easily accessible via the Trolley Train. Guests can also explore attractions like Albright-Knox Art Gallery and Darwin Martin House within several blocks.

Medical Proximity

This hotel is situated near the Buffalo Niagara Medical Campus, a key district for healthcare professionals and families. Roswell Park Comprehensive Cancer Center, John R. Oishei Children's Hospital, and Buffalo General Hospital are all within a few blocks. This accessibility makes the hotel a convenient choice for medical travelers.

Unique Accommodation

All guest rooms are spacious suites featuring a separate bedroom with a king bed and a living area with a pullout couch. Each suite includes two 49-inch TVs, a microwave, a mini fridge, and a Keurig maker for added convenience. The hotel's layout encourages privacy, making it suitable for families and longer stays.

Dining Options

Adjacent to the hotel is TGI Friday's, offering lunch and dinner in a family-friendly atmosphere. Guests can start their day with the complimentary Express Start breakfast, featuring hot items such as eggs, pancakes, and cinnamon buns. The breakfast buffet ensures guests fuel up before exploring the sights of Buffalo.

Business and Fitness Facilities

The hotel includes a 24-hour business center with free printing services, catering to business travelers. A fitness center equipped with treadmills, free weights, and stretching bands is available for workouts. Additional services such as check-in and check-out enhancements are designed for guest convenience.

Highlights

Location: Downtown Buffalo's Theatre District

Medical: Near Buffalo Niagara Medical Campus

Rooms: Spacious suites with separate living areas

Dining: On-site TGI Friday's restaurant

Breakfast: Complimentary hot breakfast buffet

“This downtown property stands out for its practical location near the convention center and theater district. I appreciate the thoughtful extras geared toward business and medical travelers, including the on-site dining and proximity to passport services. The inclusion of free transport to nearby attractions adds considerable value for those looking to explore the area.”
Hotel logo
James DavidEditor-in-Chief at Cheaphotels
View all

Select your room type

The hotel provides a selection of rooms—doubles, family rooms, and suites—with perks like free cancellation, breakfast options, and great value deals
Queen Suite Roll Shower Disability Access
2 persons
455 sq. feet 
1 King-size bed
Shower
Heating
One-Bedroom King Suite
2 persons
455 sq. feet 
1 King-size bed and 1 Sofa bed
Heating
Bathtub
Standard Room
2 persons
455 sq. feet 
1 Double bed
Heating
Bathtub
One-Bedroom Queen Room Mobility Accessible Tub Non-Smoking
2 persons
455 sq. feet 
1 King-size bed
Heating
Bathtub
Click button to see more rooms
Show all rooms
Show all roomsLess

Room rates & availability calendar

See the best prices and book your dates today!

Amenities & services

Real traveler stories and honest reviews—no glossy ads, just authentic feedback to guide your booking

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Security
  • Luggage storage
  • Lift
  • Vending machines
  • Smoke detectors
  • Fire extinguishers
  • Key card access
  • Key access

Sports & Fitness

  • Fitness centre

Services

  • Housekeeping
  • Laundry
  • Dry cleaning

Business

  • Business centre
  • Fax/Photocopying

Children

  • Board games

Spa & Leisure

  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Tea and coffee facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
Show more

Location

601 Main Street, Buffalo, New York, United States, 14203
Map view
601 Main Street, Buffalo, New York, United States, 14203
Nearby
Event hall
Buffalo Convention Center
900 ft
Main and Chippewa Streets
Fountain Plaza
300 ft
One M&T Plaza
One M&T Plaza
400 ft
780 Main St at Edward St.
Saint Louis RC Church
1900 ft
Gallery
Western New York Book Arts Collaborative
1300 ft
Library
Buffalo and Erie County Public Library
1000 ft
West Chippewa Street
Chippewa Club Zone
800 ft
617 Main St
Market Arcade Building
200 ft
Gallery
CEPA Gallery
200 ft
535 Washington St
The Electric Tower
700 ft
Restaurants
EXPO Market
400 ft
617 Main St Ste 200
Breezy Burrito Co
700 ft
617 Main St
Prima Pizza Pasta
500 ft
396 Pearl St Corner of Chippewa St
Mighty Taco
600 ft
52 W Chippewa St
La Delicias Taqueria
900 ft
454 Pearl St
Tim Hortons
900 ft
424 Main St Rm 1102
Spot Coffee
1100 ft
225 Delaware Avenue
Tap House Pub & Grill
1000 ft
85 W Chippewa St
Jim's Steakout
1100 ft
92 W Chippewa St
Jake's Cafe
1300 ft
250 Delaware Ave
Explore Buffalo
Explore Buffalo
Top Attractions
Activities
Dining
Entertainment
Buffalo Convention Center
Buffalo Convention Center
4 minutes' walk
A hub for major events and conventions, featuring impressive architecture and various exhibits throughout the year.
Soldiers' and Sailors' Monument
Soldiers' and Sailors' Monument
8 minutes' walk
A tribute to veterans, showcasing detailed sculptures. The site offers historical insights and beautiful views.
Theodore Roosevelt Inaugural National Historic Site
Theodore Roosevelt Inaugural National Historic Site
19 minutes' walk
The birthplace of modern America features guided tours and interpretative displays, highlighting Roosevelt's impact.
Canalside
Canalside
20 minutes' walk
A waterfront destination with activities, events, and dining options. Perfect for families and enjoyment on warmer days.
Silo City Tours
15 minutes' walk
Guided tours of historic grain silos showcasing Buffalo's industrial past and art installations. Seasonal availability.
Buffalo Zoo
5 minutes' drive
An engaging experience for families featuring over 1,000 animals. Ideal for a day of relaxation amidst nature.
Biking along the Waterfront
20 minutes' walk
Bike rentals available near Canalside for a scenic ride along the waterfront, suitable for all skill levels.
EXPO Market
EXPO Market
2 minutes' walk
A vibrant food hall offering local specialties and casual dining options to satisfy diverse tastes from breakfast to dinner.
Breezy Burrito Co
Breezy Burrito Co
3 minutes' walk
Casual eatery known for its fresh burritos and tacos, perfect for a quick and satisfying meal. Vegetarian options available.
La Delicias Taqueria
La Delicias Taqueria
4 minutes' walk
Authentic Mexican cuisine in a cozy setting with hearty portions and flavorful dishes. Reservations recommended for busy nights.
KeyBank Center
KeyBank Center
25 minutes' walk
Home to concerts and sports events, offering a lively atmosphere. Check the calendar for family-friendly shows.
Buffalo Comedy Barn
6 minutes' drive
A fun venue featuring stand-up comedy and open-mic nights. A great spot for a relaxed evening filled with laughter.
Getting around town
City Centre
Buffalo3 min  ·  700 ft
Airports
Buffalo Niagara International Airport (BUF)24 min  ·  9.9 mi
Niagara Falls International Airport (IAG)49 min  ·  20.2 mi
Train
Buffalo, NY Station16 min  ·  4300 ft
Bus
Bus stop3 min  ·  700 ft
Looking for early-bird discounts?
Get special discounted rates today!
Check Rates
Property information and rules
Check-in
from 15:00-23:59
Check-out
until 11 am
Guest Parking
Paid Public parking is possible at a location nearby.
Internet
is available in for free.
Breakfast
The hotel Holiday Inn Express & Suites Buffalo Downtown By Ihg serves a full breakfast for free. 
Children & extra beds
There are no cots provided in a room. 
Pets
Pets are not allowed.
Number of floors:
7
Number of rooms:
146
Former name
Comfort Suites
FAQs
About Holiday Inn Express & Suites Buffalo Downtown By Ihg
What are the check-in and check-out times at Holiday Inn Express & Suites Buffalo Downtown By Ihg?
Check-in is at 15:00 and check-out is at 11:00.
How far is Holiday Inn Express & Suites Buffalo Downtown By Ihg from Buffalo Niagara International Airport?
The hotel is located 20 km from Buffalo Niagara International Airport, approximately a 16-minute drive.
What amenities are available in the rooms at Holiday Inn Express & Suites Buffalo Downtown By Ihg?
Rooms include free Wi-Fi, air conditioning, a flat-screen TV, a microwave, a refrigerator, and a sofa bed.
What dining options are available near Holiday Inn Express & Suites Buffalo Downtown By Ihg?
Nearby restaurants include Bacchus Wine Bar & Restaurant, Breezy Burrito Co, and Dinosaur Bar-B-Que, all within 0.5 km.
What amenities does Holiday Inn Express & Suites Buffalo Downtown By Ihg offer for business travelers?
The hotel features a business center, complimentary Wi-Fi, and express check-in/check-out.
Does Holiday Inn Express & Suites Buffalo Downtown By Ihg have on-site parking?
The hotel does not have dedicated on-site parking, but public parking is available nearby.
What are the fitness options at Holiday Inn Express & Suites Buffalo Downtown By Ihg?
Guests have access to a 24-hour fitness center.
What breakfast options does Holiday Inn Express & Suites Buffalo Downtown By Ihg provide?
The hotel offers a complimentary hot breakfast buffet each morning.
What attractions are within walking distance of Holiday Inn Express & Suites Buffalo Downtown By Ihg?
Nearby attractions include Shea's Performing Arts Center, Buffalo Niagara Convention Center, and Key Bank Center.
Is there a shuttle service available at Holiday Inn Express & Suites Buffalo Downtown By Ihg?
The hotel offers a free shuttle service to local destinations, including casinos and events.
What entertainment options are near Holiday Inn Express & Suites Buffalo Downtown By Ihg?
Guests can enjoy local events and attractions, including concerts at the Town Ballroom and dining venues in the Chippewa Club Zone.

Next best alternative

Consider them for your next trip.
Check-in
27Jan2026Select date
Check-out
28Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Need more options?
Check Top hotels near Holiday Inn Express & Suites Buffalo Downtown By Ihg
The Hilton Garden Inn Buffalo-Downtown Exterior photo
Mobile-only price

The Hilton Garden Inn Buffalo-Downtown

7.9
Very good491 reviews
469m from property
USD 139USD 125
per night
Best Western On The Avenue Buffalo Interior photo
Mobile-only price

Best Western On The Avenue Buffalo

8.4
Great832 reviews
897m from property
USD 128USD 115
per night
Ramada By Wyndham Buffalo Downtown Skyline photo
Mobile-only price

Ramada By Wyndham Buffalo Downtown

5.0
Guest rating487 reviews
1038m from property
USD 59USD 53
per night